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Publications

Within the GRK 2336, research projects study the cells and mediators involved in resolution-associated processes as well as the signaling cascades and target structures involved - with the aim of identifying alterations linked to dysregulated resolution of inflammation. Projects make use of primary human material, preclinically relevant animal models and cellular systems combined with biochemical, molecular biology, pharmacological and systems biology approaches. Especially in the last 3 years many findings within the research projects itself, in cooperation within the GRK and in cooperation with external partners have been published. The members of the GRK are underlined, the students members are highlighted in bold in addition.

Publications in chronical order:

  1. Schierle S, Flauaus C, Heitel P, Willems S, Schmidt J, Kaiser A, Weizel L, Goebel T, Kahnt AS, Geisslinger G, Steinhilber D, Wurglics M, Rovati GE, Schmidtko A, Proschak E, Merk D. (2018) Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology. J Med Chem. 12;61(13):5758-5764. doi: 10.1021/acs.jmedchem.8b00458.
  2. Heitel P, Gellrich L, Heering J, Goebel T, Kahnt A, Proschak E, Schubert-Zsilavecz M, Merk D. (2018) Urate transporter inhibitor lesinurad is a selective peroxisome proliferator-activated receptor gamma modulator (sPPARγM) in vitro. Sci Rep. 8(1):13554. doi: 10.1038/s41598-018-31833-4.
  3. Winslow S, Scholz A, Rappl P, Brauß TF, Mertens C, Jung M, Weigert A, Brüne B, Schmid T (2019) Macrophages attenuate the transcription of CYP1A1 in breast tumor cells and enhance their proliferation. PLoS ONE 14,e0209694. doi: 10.1371/journal.pone.0209694.
  4. Wehbi B, Oblet C, Boyer F, Huard A, Druilhe A, Paraf F, Cogné E, Moreau J, El Makhour Y, Badran B, Van Egmond M, Cogné M, Aldigier JC. (2019) Mesangial Deposition Can Strongly Involve Innate-Like IgA Molecules Lacking Affinity Maturation. J Am Soc Nephrol. 30(7):1238-1249. doi: 10.1681/ASN.2018111089.
  5. Bräutigam J, Bischoff I, Schürmann C, Buchmann G, Epah J, Fuchs S, Heiss E, Brandes RP, Fürst R. (2019) Narciclasine inhibits angiogenic processes by activation of Rho kinase and by downregulation of the VEGF receptor 2. J Mol Cell Cardiol. Oct;135:97-108. doi: 10.1016/j.yjmcc.2019.08.001.
  6. Tarighi, N, Menger, D, Pierre, S, Kornstädt, L, Thomas, D, Ferreirós, N, Nüsing, RM, Geisslinger, G, Scholich, K (2019). Thromboxane-Induced α-CGRP Release from Peripheral Neurons Is an Essential Positive Feedback Loop in Capsaicin-Induced Neurogenic Inflammation. The Journal of Investigative Dermatology, 139(3), 656–664. doi.org/10.1016/j.jid.2018.10.01
  7. Syed SN, Raue R, Weigert A, von Knethen A, Brüne B. (2019) Macrophage S1PR1 Signaling Alters Angiogenesis and Lymphangiogenesis During Skin Inflammation. Cells. Jul 28;8(8):785. doi: 10.3390/cells8080785.
  8. Syed SN, Frank AC, Raue R, Brüne B. (2019) MicroRNA-A Tumor Trojan Horse for Tumor-Associated Macrophages. Cells. 21;8(12):1482. doi: 10.3390/cells8121482.
  9. Stark A, Schwenk R, Wack G, Zuchtriegel G, Hatemler MG, Bräutigam J, Schmidtko A, Reichel CA, Bischoff I, Fürst R (2019) Narciclasine exerts anti-inflammatory actions by blocking leukocyte-endothelial cell interactions and down-regulation of the endothelial TNF receptor 1. FASEB J. 33(8):8771-8781. doi: 10.1096/fj.201802440R.
  10. Göbel T, Diehl O, Heering J, Merk D, Angioni C, Wittmann SK, Buscato E, Kottke R, Weizel L, Schader T, Maier TJ, Geisslinger G, Schubert-Zsilavecz M, Steinhilber D, Proschak E, Kahnt AS (2019) 1Zafirlukast Is a Dual Modulator of Human Soluble Epoxide Hydrolase and Peroxisome Proliferator-Activated Receptor γ. Front Pharmacol. 0:263. doi: 10.3389/fphar.2019.00263.
  11. Schürmann C, Dienst FL, Pálfi K, Vasconez AE, Oo JA, Wang S, Buchmann GK, Offermanns S, van de Sluis B, Leisegang MS, Günther S, Humbert PO, Lee E, Zhu J, Weigert A, Mathoor P, Wittig I, Kruse C, Brandes RP (2019) The polarity protein Scrib limits atherosclerosis development in mice. Cardiovascular research. 115:1963–1974. doi: 10.1093/cvr/cvz093.
  12. Martin LM, Möller M, Weiss U, Russe OQ, Scholich K, Pierre S, Geisslinger G, Niederberger E (2019) 5-Amino-1-β-D-Ribofuranosyl-Imidazole-4-Carboxamide (AICAR) Reduces Peripheral Inflammation by Macrophage Phenotype Shift. Int J Mol Sci. 20(13):3255. doi: 10.3390/ijms20133255
  13. Han Y*, Mora J*, Huard A, da Silva P, Wiechmann S, Putyrski M, Schuster C, Elwakeel E, Lang G, Scholz A, Scholz T, Schmid T, de Bruin N, Billuart P, Sala C, Burkhardt H, Parnham MJ, Ernst A, Brüne B, Weigert A (2019) IL-38 Ameliorates Skin Inflammation and Limits IL-17 Production from γδ T Cells. Cell Rep. 27(3):835-846.e5. doi: 10.1016/j.celrep.2019.03.082. * contributed equally
  14. Gellrich L, Heitel P, Heering J, Kilu W, Pollinger J, Goebel T, Kahnt A, Arifi S, Pogoda W, Paulke A, Steinhilber D, Proschak E, Wurglics M, Schubert-Zsilavecz M, Chaikuad A, Knapp S, Bischoff I, Fürst R, Merk D (2020) l-Thyroxin and the Nonclassical Thyroid Hormone TETRAC Are Potent Activators of PPARγ. J Med Chem. 63(13):6727-6740. doi: 10.1021/acs.jmedchem.9b02150.
  15. Ebert R, Cumbana R, Lehmann C, Kutzner L, Toewe A, Ferreirós N, Parnham MJ, Schebb NH, Steinhilber D, Kahnt AS (2020) Long-term stimulation of toll-like receptor-2 and -4 upregulates 5-LO and 15-LO-2 expression thereby inducing a lipid mediator shift in human monocyte-derived macrophages. Biochim Biophys Acta Mol Cell Biol Lipids. 1865(9):158702. doi: 10.1016/j.bbalip.2020.158702.
  16. Cohnen, J, Kornstädt, L, Hahnefeld, L, Ferreiros, N, Pierre, S, Koehl, U, Deller, T, Geisslinger, G, Scholich, K (2020). Tumors Provoke Inflammation and Perineural Microlesions at Adjacent Peripheral Nerves. Cells. https://doi.org/10.3390/cells9020320
  17. Buchmann GK, Schürmann C, Warwick T, Schulz MH, Spaeth M, Müller OJ, Schröder K, Jo H, Weissmann N, Brandes RP (2020) Deletion of NoxO1 limits atherosclerosis development in female mice. Redox biology. 37:101713. doi: 10.1016/j.redox.2020.101713
  18. Wanior M, Preuss F, Ni X, Krämer A, Mathea S, Göbel T, Heidenreich D, Simonyi S, Kahnt AS, Joerger AC, Knapp S (2020) Pan-SMARCA/PB1 Bromodomain Inhibitors and Their Role in Regulating Adipogenesis. J Med Chem. 10;63(23):14680-14699. doi: 10.1021/acs.jmedchem.0c01242.
  19. von Hegedus JH, Kahnt AS, Ebert R, Heijink M, Toes REM, Giera M, Ioan-Facsinay A. (2020) Toll-like receptor signaling induces a temporal switch towards a resolving lipid profile in monocyte-derived macrophages. Biochim Biophys Acta Mol Cell Biol Lipids. 1865(9):158740. doi: 10.1016/j.bbalip.2020.158740.
  20. Sirait-Fischer E, Olesch C, Fink AF, Berkefeld M, Huard A, Schmid T, Takeda K, Brüne B, Weigert A (2020) Immune Checkpoint Blockade Improves Chemotherapy in the PyMT Mammary Carcinoma Mouse Model. Front. Oncol. 10;10:1771. doi: 10.3389/fonc.2020.01771.
  21. Seimetz M, Sommer N, Bednorz M, Pak O, Veith C, Hadzic S, Gredic M, Parajuli N, Kojonazarov B, Kraut S, Wilhelm J, Knoepp F, Henneke I, Pichl A, Kanbagli ZI, Scheibe S, Fysikopoulos A, Wu C-Y, Klepetko W, Jaksch P, Eichstaedt C, Grünig E, Hinderhofer K, Geiszt M, Müller N, Rezende F, Buchmann G, Wittig I, Hecker M, Hecker A, Padberg W, Dorfmüller P, Gattenlöhner S, Vogelmeier CF, Günther A, Karnati S, Baumgart-Vogt E, Schermuly RT, Ghofrani HA, Seeger W, Schröder K, Grimminger F, Brandes RP, Weissmann N. (2020) NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD. Nat Metab. 2:532–546. doi: 10.1038/s42255-020-0215-8. Erratum in: Nat Metab. 2(7):648.
  22. Scholz A, Rappl P, Böffinger N, Mota AC, Brüne B, Schmid T (2020) Translation of TNFAIP2 is tightly controlled by upstream open reading frames. Cell Mol Life Sci. 77, 2017-2027. doi: 10.1007/s00018-019-03265-4.
  23. Rehwald C, Schnetz M, Urbschat A, Mertens C, Meier JK, Bauer R, Baer P, Winslow S, Roos FC, Zwicker K, Huard A, Weigert A, Brüne B, Jung M. (2020) The iron load of lipocalin-2 (LCN-2) defines its pro-tumour function in clear-cell renal cell carcinoma. Br J Cancer. 122(3):421-433. doi: 10.1038/s41416-019-0655-7.
  24. Mosa, MH, Michels, BE, Menche, C, Nicolas, AM, Darvishi, T, Greten, FR, Farin, HF (2020). A Wnt-Induced Phenotypic Switch in Cancer-Associated Fibroblasts Inhibits EMT in Colorectal Cancer. Cancer Res. 80(24):5569-5582. doi: 10.1158/0008-5472.CAN-20-0263..
  25. Möller M, Wasel J, Schmetzer J, Weiß U, Meissner M, Schiffmann S, Weigert A, Möser CV, Niederberger E (2020) The Specific IKKε/TBK1 Inhibitor Amlexanox Suppresses Human Melanoma by the Inhibition of Autophagy, NF-κB and MAP Kinase Pathways. Int J Mol Sci. 21(13):4721. doi: 10.3390/ijms21134721
  26. Schuster C, Huard A, Sirait-Fischer E, Dillmann C, Brüne B, Weigert A (2020) S1PR4-dependent CCL2 production promotes macrophage recruitment in a murine psoriasis model. Eur J Immunol. 50(6):839-845. doi: 10.1002/eji.201948349.
  27. Varga J, Nicolas A, Petrocelli V, Pesic M, Mahmoud A, Michels BE, Etlioglu E, Yepes D, Häupl B, Ziegler PK, Bankov K, Wild PJ, Wanninger S, Medyouf H, Farin HF, Tejpar S, Oellerich T, Ruland J, Siebel CW, Greten FR (2020) AKT-dependent NOTCH3 activation drives tumor progression in a model of mesenchymal colorectal cancer. J Exp Med. Oct 5;217(10):e20191515. doi: 10.1084/jem.20191515. PMID: 32749453; PMCID: PMC7537393.
  28. Bachmann M, Lamprecht L, Gonther S, Pfeilschifter J, Mühl H. (2020) A murine cellular model of necroinflammation displays RAGE-dependent cytokine induction that connects to hepatoma cell injury. J Cell Mol Med. Sep;24(18):10356-10366. doi: 10.1111/jcmm.15649.
  29. Kesevan R, Frömel T, Zukunft S, Laban H, Geyer A, Naeem Z, Heidler J, Wittig I, Elwakeel E, Brüne B, Weigert A, Popp R, Fleming I (2020) Cyp2c44 regulates prostaglandin synthesis, lymphangiogenesis and metastasis in a mouse model of breast cancer. Proc Natl Acad Sci U S A. 117(11):5923-5930. doi: 10.1073/pnas.1921381117.
  30. Weiss, U, Möller, M, Husseini, SA, Manderscheid, C, Häusler, J, Geisslinger, G, Niederberger, E (2020). Inhibition of HDAC enzymes contributes to differential expression of pro-inflammatory proteins in the TLR-4 signaling cascade. Int J Mol Sci. 2020 Nov 25;21(23):8943. doi: 10.3390/ijms21238943.
  31. Han Y, Huard A, Mora J, da Silva P, Brüne B, Weigert A (2020) IL-36 family cytokines in protective versus destructive inflammation. Cell Signal. Nov;75:109773. doi: 10.1016/j.cellsig.2020.109773.
  32. Huard A, Do HN, Frank AC, Sirait-Fischer E, Fuhrmann D, Hofmann MCJ, Raue R, Palmer G, Brüne B, de Bruin N, Weigert A. IL-38 Ablation Reduces Local Inflammation and Disease Severity in Experimental Autoimmune Encephalomyelitis. J Immunol. 2021 Mar 1;206(5):1058-1066. doi: 10.4049/jimmunol.2000923. Epub 2021 Jan 27. PMID: 33504620.
  33. Hahnefeld, L*, Kornstädt, L*, Kratz, D, Ferreirós, N, Geisslinger, G, Pierre, S, Scholich, K (2021). Lipidomic analysis of local inflammation models shows a specific systemic acute phase response to lipopolysaccharides. Biochim Biophys Acta Mol Cell Biol Lipids., 1866(1), 158822. doi: 10.1016/j.bbalip.2020.158822. * contributed equally
  34. Rappl P, Rösser S, Maul P, Bauer R, Huard A, Schreiber Y, Thomas D, Geisslinger G, Jakobsson J, Weigert A, Brüne B, Schmid T. (2021) Inhibition of mPGES-1 attenuates efficient resolution of acute inflammation. Cell Death Dis. 12(2):135. doi: 10.1038/s41419-021-03423-2.
  35. Rappl P, Brüne B, Schmid T. (2021) Role of Tristetraprolin in the Resolution of Inflammation. Biology (Basel). 10(1):66. doi: 10.3390/biology10010066.
  36. Kornstädt, L, Pierre, S, Weigert, A, Ebersberger, S, Schäufele, TJ, Kolbinger, A, Schmid, T, Cohnen, J, Thomas, D, Ferreirós, N, Brüne, B, Ebersberger, I, Scholich, K (2021) Bacterial and fungal toll-like receptor activation elicits type I IFN responses in mast cells. Front. Immunol., 12 Feb. doi.org/10.3389/fimmu.2020.607048
  37. Knuth AK, Huard A, Naeem Z, Rappl P, Bauer R, Mota AC, Schmid T, Fleming I, Brüne B, Fulda S*, Weigert A*. (2021) Apoptotic Cells induce Proliferation of Peritoneal Macrophages. Int J Mol Sci. Feb 24;22(5):2230. doi: 10.3390/ijms22052230. PMID: 33668084; PMCID: PMC7956251. *Corresponding authors
  38. Krishnathas GM, Strödke B, Mittmann L, Zech T, Berger LM, Reichel CA, Rösser S, Schmid T, Knapp S, Müller S, Bracher F, Fürst R, Bischoff-Kont I. C81-evoked inhibition of the TNFR1-NFκB pathway during inflammatory processes for stabilization of the impaired vascular endothelial barrier for leukocytes. FASEB J. 2021 Jun;35(6):e21656. doi: 10.1096/fj.202100037R.
  39. Buchmann GK, Schürmann C, Spaeth M, Abplanalp W, Tombor L, John D, Warwick T, Rezende F, Weigert A, Shah AM, Hansmann ML, Weissmann N, Dimmeler S, Schröder K, Brandes RP. (2021). The hydrogen-peroxide producing NADPH oxidase 4 does not limit neointima development after vascular injury in mice. Redox biology, 45, 102050. https://doi.org/10.1016/j.redox.2021.102050
  40. Bojkova D, Costa R, Reus P, Bechtel M, Jaboreck M-C, Olmer R, Martin U, Ciesek S, Michaelis M, Cinatl J Jr.. Targeting the Pentose Phosphate Pathway for SARS-CoV-2 Therapy. Metabolites. 2021; 11(10):699. https://doi.org/10.3390/metabo11100699
  41. Frank AC, Raue R, Fuhrmann DC, Sirait-Fischer E, Reuse C, Weigert A, Lütjohann D, Hiller K, Syed SN, Brüne B. Lactate dehydrogenase B regulates macrophage metabolism in the tumor microenvironment. Theranostics. 2021 Jun 4;11(15):7570-7588. doi: 10.7150/thno.58380. PMID: 34158867; PMCID: PMC8210612.
  42. Reus P, Schneider A-K, Ulshöfer T, Henke M, Bojkova D, Cinatl J, Ciesek S, Geisslinger G, Laux V, Grättinger M, Gribbon P, Schiffmann S. Characterization of ACE Inhibitors and AT1R Antagonists with Regard to Their Effect on ACE2 Expression and Infection with SARS-CoV-2 Using a Caco-2 Cell Model. Life. 2021; 11(8):810. https://doi.org/10.3390/life11080810
  43. Raue R, Frank AC, Syed SN, Brüne B. Therapeutic Targeting of MicroRNAs in the Tumor Microenvironment. Int J Mol Sci. 2021 Feb 23;22(4):2210. doi: 10.3390/ijms22042210. PMID: 33672261; PMCID: PMC7926641.
  44. McLaughlin* K-M, Bojkova* D, Kandler* JD, Bechtel M, Reus P, Le T, Rothweiler F, Wagner JUG, Weigert A, Ciesek S, Wass MN, Michaelis M, Cinatl J (2021) A Potential Role of the CD47/SIRPalpha Axis in COVID-19 Pathogenesis. Curr. Issues Mol. Biol. 2021, 43, 1212–1225. doi:10.3390/cimb43030086 *contributed equally
  45. Stülb H, Bachmann M, Gonther S, Mühl H. (2021) Acetaminophen-Induced Liver Injury Exposes Murine IL-22 as Sex-Related Gene Product. Int J Mol Sci. Sep 30;22(19):10623. doi: 10.3390/ijms221910623.
  46. Tirado-Gonzalez I, Descot A, Soetopo D, Nevmerzhitskaya A, Schäffer A, Kur IM, Czlonka E, Wachtel C, Tsoukala I, Müller, L., Schäfer AL, Weitmann M, Dinse P, Alberto E, Buck MC, Landry J J, Baying B, Slotta-Huspenina J, Roesler J, Harter PN, Kubasch AS, Meinel J, Elwakeel E, Strack E, Quang CT, Abdel-Wahab O, Schmitz M, Weigert A, Schmid T, Platzbecker U, Benes V, Ghysdael J, Bonig H, Götze KS, Rothlin CV, Ghosh S, Medyouf H (2021). AXL Inhibition in Macrophages Stimulates Host-versus-Leukemia Immunity and Eradicates Naïve and Treatment-Resistant Leukemia. Cancer discovery, 11(11), 2924–2943. https://doi.org/10.1158/2159-8290.CD-20-1378
  47. de Bruin N, Schneider AK, Reus P, Talmon S, Ciesek S, Bojkova D, Cinatl J, Lodhi I, Charlesworth B, Sinclair S, Pennick G, Laughey WF, Gribbon P, Kannt A, Schiffmann S (2022). Ibuprofen, Flurbiprofen, Etoricoxib or Paracetamol Do Not Influence ACE2 Expression and Activity In Vitro or in Mice and Do Not Exacerbate In-Vitro SARS-CoV-2 Infection. Infection. Int J Mol Sci. 2022 Jan 19;23(3):1049. doi: 10.3390/ijms23031049. PMID: 35162972; PMCID: PMC8835123.
  48. Gonther S, Bachmann M, Goren I, Huard A, Weigert A, Köhl J, Mühl H. 3'mRNA sequencing reveals pro-regenerative properties of c5ar1 during resolution of murine acetaminophen-induced liver injury. NPJ Regen Med. 2022 Jan 27;7(1):10. doi: 10.1038/s41536-022-00206-x. PMID: 35087052; PMCID: PMC8795215.#
  49. Heering J, Hernandez-Olmos V, Ildefeld N, Liu T, Kaiser A, Naeem Z, Frömel T, Fleming I, Steinhilber D, Proschak E. Development and Characterization of a Fluorescent Ligand for Leukotriene B4 Receptor 2 in Cells and Tissues. J Med Chem. 2022 Feb 10;65(3):2023-2034. doi: 10.1021/acs.jmedchem.1c01589
  50. Raue R, Frank AC, Fuhrmann DC, de la Cruz-Ojeda P, Rösser S, Bauer R, Cardamone G, Weigert A, Syed SN, Schmid T, Brüne B. MicroRNA-200c Attenuates the Tumor-Infiltrating Capacity of Macrophages. Biology (Basel). 2022 Feb 22;11(3):349. doi: 10.3390/biology11030349. PMID: 35336722
  51. Nicolas AM, Pesic M, Engel E, Ziegler PK, Diefenhardt M, Kennel KB, Buettner F, Conche C, Petrocelli V, Elwakeel E, Weigert A, Zinoveva A, Fleischmann M, Häupl B, Karakütük C, Bohnenberger H, Mosa MH, Kaderali L, Gaedcke J, Ghadimi M, Rödel F, Arkan MC, Oellerich T, Rödel C, Fokas E, Greten FR. Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer. Cancer Cell. 2022 Feb 14;40(2):168-184.e13. doi: 10.1016/j.ccell.2022.01.004. Epub 2022 Feb 3. PMID: 35120600. / Cover Article Feb 2022
  52. Bischoff-Kont I, Primke T, Niebergall LS, Zech T, Fürst R. Ginger Constituent 6-Shogaol Inhibits Inflammation- and Angiogenesis-Related Cell Functions in Primary Human Endothelial Cells. Front Pharmacol. 2022 Feb 25;13:844767. doi: 10.3389/fphar.2022.844767. PMID: 35281937; PMCID: PMC8914105.
  53. Mainka M, George S, Angioni C, Ebert R, Goebel T, Kampschulte N, Krommes A, Weigert A, Thomas D, Schebb NH, Steinhilber D, Kahnt AS. On the biosynthesis of specialized pro-resolving mediators in human neutrophils and the influence of cell integrity. Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Mar;1867(3):159093. doi: 10.1016/j.bbalip.2021.159093. Epub 2021 Dec 21. PMID: 34942381.
  54. Fleischmann M, Diefenhardt M, Nicolas AM, Rödel F, Ghadimi M, Hofheinz RD, Greten FR, Rödel C, Fokas E; German Rectal Cancer Study Group. ACO/ARO/AIO-21 - Capecitabine-based chemoradiotherapy in combination with the IL-1 receptor antagonist anakinra for rectal cancer Patients: A phase I trial of the German rectal cancer study group. Clin Transl Radiat Oncol. 2022 Apr 6;34:99-106. doi: 10.1016/j.ctro.2022.04.003. PMID: 35449546; PMCID: PMC9018120.
  55. Elwakeel E, Brüggemann M, Wagih J, Lityagina O, Elewa MAF, Han Y, Frömel T, Popp R, Nicolas AM, Schreiber Y, Gradhand E, Thomas D, Nüsing R, Steinmetz-Späh J, Savai R, Fokas E, Fleming I, Greten FR, Zarnack K, Brüne B, Weigert A. Disruption of Prostaglandin E2 Signaling in Cancer-Associated Fibroblasts Limits Mammary Carcinoma Growth but Promotes Metastasis. Cancer Res. 2022 Apr 1;82(7):1380-1395. doi: 10.1158/0008-5472.CAN-21-2116. PMID: 35105690.
  56. Sekar D, Dillmann C, Sirait-Fischer E, Fink AF, Zivkovic A, Baum N, Strack E, Klatt S, Zukunft S, Wallner S, Descot A, Olesch C, da Silva P, von Knethen A, Schmid T, Grösch S, Savai R, Ferreirós N, Fleming I, Ghosh S, Rothlin CV, Stark H, Medyouf H, Brüne B, Weigert A. Phosphatidylserine Synthase PTDSS1 Shapes the Tumor Lipidome to Maintain Tumor-Promoting Inflammation. Cancer Res. 2022 Apr 15;82(8):1617-1632. doi: 10.1158/0008-5472.CAN-20-3870. PMID: 35425959.
  57. Kolbinger A, Kestner RI, Jencio L, Schäufele TJ, Vutukuri R, Pfeilschifter W, Scholich K. Behind the Wall-Compartment-Specific Neovascularisation during Post-Stroke Recovery in Mice. Cells. 2022 May 17;11(10):1659. doi: 10.3390/cells11101659. PMID: 35626695; PMCID: PMC9139871.
  58. Bauer R, Meyer SP, Kloss KA, Guerrero Ruiz VM, Reuscher S, Zhou Y, Fuhrmann DC, Zarnack K, Schmid T, Brüne B. Functional RNA Dynamics Are Progressively Governed by RNA Destabilization during the Adaptation to Chronic Hypoxia. Int J Mol Sci. 2022 May 22;23(10):5824. doi: 10.3390/ijms23105824. PMID: 35628634; PMCID: PMC9144826.
  59. Ukan Ü, Delgado Lagos F, Kempf S, Günther S, Siragusa M, Fisslthaler B, Fleming I. Effect of Thrombin on the Metabolism and Function of Murine Macrophages. Cells. 2022 May 23;11(10):1718. doi: 10.3390/cells11101718. PMID: 35626753; PMCID: PMC9139186.
  60. Möller M, Möser CV, Weiß U, Niederberger E. The Role of AlphαSynuclein in Mouse Models of Acute, Inflammatory and Neuropathic Pain. Cells. 2022 Jun 19;11(12):1967. doi: 10.3390/cells11121967. PMID: 35741096; PMCID: PMC9221919.
  61. Frömel T, Naeem Z, Pirzeh L, Fleming I. Cytochrome P450-derived fatty acid epoxides and diols in angiogenesis and stem cell biology. Pharmacol Ther. 2022 Jun;234:108049. doi: 10.1016/j.pharmthera.2021.108049 PMID: 34848204.
  62. Burgers LD, Li Y, Michalakis S, Ciurus S, Zahler S, Müller R, Fürst R. The protein biosynthesis inhibitor vioprolide A evokes anti-angiogenic and pro-survival actions by targeting NOP14 and decreasing VEGF receptor 2- and TAZ-signaling. Biomed Pharmacother. 2022 Aug;152:113174. doi: 10.1016/j.biopha.2022.113174. Epub 2022 Jun 2. PMID: 35665668.
  63. Naeem Z, Zukunft S, Günther S, Liebner S, Weigert A, Hammock BD, Frömel T, Fleming I. Role of the soluble epoxide hydrolase in the hair follicle stem cell homeostasis and hair growth. Pflugers Arch. 2022 Sep;474(9):1021-1035. doi: 10.1007/s00424-022-02709-4. PMID: 35648219; PMCID: PMC9393123.
  64. Kreiß M, Oberlis JH, Seuter S, Bischoff-Kont I, Sürün D, Thomas D, Göbel T, Schmid T, Rådmark O, Brandes RP, Fürst R, Häfner AK, Steinhilber D. Human 5-lipoxygenase regulates transcription by association to euchromatin. Biochem Pharmacol. 2022 Sep;203:115187. doi: 10.1016/j.bcp.2022.115187. Epub 2022 Jul 22. PMID: 35878796.
  65. Denk D, Petrocelli V, Conche C, Drachsler M, Ziegler PK, Braun A, Kress A, Nicolas AM, Mohs K, Becker C, Neurath MF, Farin HF, Buchholz CJ, Andreux PA, Rinsch C, Greten FR. Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy. Immunity. 2022 Nov 8;55(11):2059-2073.e8. doi: 10.1016/j.immuni.2022.09.014. Epub 2022 Oct 19. PMID: 36351375.
  66. Oo JA, Pálfi K, Warwick T, Wittig I, Prieto-Garcia C, Matkovic V, Tomašković I, Boos F, Izquierdo Ponce J, Teichmann T, Petriukov K, Haydar S, Maegdefessel L, Wu Z, Pham MD, Krishnan J, Baker AH, Günther S, Ulrich HD, Dikic I, Leisegang MS, Brandes RP. Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2. Cell Rep. 2022 Nov 15;41(7):111670. doi: 10.1016/j.celrep.2022.111670. PMID: 36384122; PMCID: PMC9681662.
  67. Bojkova D, Stack R, Rothenburger T, Kandler JD, Ciesek S, Wass MN, Michaelis M, Cinatl J Jr. Synergism of interferon-beta with antiviral drugs against SARS-CoV-2 variants. J Infect. 2022 Nov;85(5):573-607. doi: 10.1016/j.jinf.2022.07.023. Epub 2022 Jul 31. PMID: 35917841; PMCID: PMC9339084.
  68. Schmitt M, Ceteci F, Gupta J, Pesic M, Böttger TW, Nicolas AM, Kennel KB, Engel E, Schewe M, Callak Kirisözü A, Petrocelli V, Dabiri Y, Varga J, Ramakrishnan M, Karimova M, Ablasser A, Sato T, Arkan MC, de Sauvage FJ, Greten FR. Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation. Nature. 2022 Dec;612(7939):347-353. doi: 10.1038/s41586-022-05426-1. Epub 2022 Nov 16. PMID: 36385525; PMCID: PMC7613947.
  69. Burkard T, Herrero San Juan M, Dreis C, Kiprina A, Namgaladze D, Siebenbrodt K, Luger S, Foerch C, Pfeilschifter JM, Weigert A, Radeke HH. Differential expression of CD8 defines phenotypically distinct cytotoxic T cells in cancer and multiple sclerosis. Clin Transl Med. 2022 Dec;12(12):e1068. doi: 10.1002/ctm2.1068. PMID: 36504430; PMCID: PMC9742381.
  70. Nicolas AM, Pesic M, Rödel F, Fokas E, Greten FR. Image-guided radiotherapy in an orthotopic mouse model of rectal cancer. STAR Protoc. 2022 Dec 16;3(4):101749. doi: 10.1016/j.xpro.2022.101749. Epub 2022 Oct 5. PMID: 36206161; PMCID: PMC9547293.
  71. Kolbinger A, Schäufele TJ, Steigerwald H, Friedel J, Pierre S, Geisslinger G, Scholich K. Eosinophil-derived IL-4 is necessary to establish the inflammatory structure in innate inflammation. EMBO Mol Med. 2022 Dec 21:e16796. doi: 10.15252/emmm.202216796. Epub ahead of print. PMID: 36541656.
  72. Boos F, Oo JA, Warwick T, Günther S, Izquierdo Ponce J, Lopez M, Rafii D, Buchmann G, Pham MD, Msheik ZS, Li T, Seredinski S, Haydar S, Kashefiolasl S, Plate KH, Behr R, Mietsch M, Krishnan J, Pullamsetti SS, Bibli SI, Hinkel R, Baker AH, Boon RA, Schulz MH, Wittig I, Miller FJ Jr, Brandes RP, Leisegang MS. The endothelial-enriched lncRNA LINC00607 mediates angiogenic function. Basic Res Cardiol. 2023 Jan 26;118(1):5. doi: 10.1007/s00395-023-00978-3. PMID: 36700983; PMCID: PMC9879848.
  73. Conche C, Finkelmeier F, Pešić M, Nicolas AM, Böttger TW, Kennel KB, Denk D, Ceteci F, Mohs K, Engel E, Canli Ö, Dabiri Y, Peiffer KH, Zeuzem S, Salinas G, Longerich T, Yang H, Greten FR. Combining ferroptosis induction with MDSC blockade renders primary tumours and metastases in liver sensitive to immune checkpoint blockade. Gut. 2023 Jan 27:gutjnl-2022-327909. doi: 10.1136/gutjnl-2022-327909. Epub ahead of print. PMID: 36707233.
  74. Weisser H, Göbel T, Melissa Krishnathas G, Kreiß M, Angioni C, Sürün D, Thomas D, Schmid T, Häfner AK, Kahnt AS. Knock-out of 5-lipoxygenase in overexpressing tumor cells-consequences on gene expression and cellular function. Cancer Gene Ther. 2023 Jan;30(1):108-123. doi: 10.1038/s41417-022-00531-9. Epub 2022 Sep 16. PMID: 36114329; PMCID: PMC9842508.
  75. Bojkova D, Reus P, Panosch L, Bechtel M, Rothenburger T, Kandler JD, Pfeiffer A, Wagner JUG, Shumliakivska M, Dimmeler S, Olmer R, Martin U, Vondran FWR, Toptan T, Rothweiler F, Zehner R, Rabenau HF, Osman KL, Pullan ST, Carroll MW, Stack R, Ciesek S, Wass MN, Michaelis M, Cinatl J Jr. Identification of novel antiviral drug candidates using an optimized SARS-CoV-2 phenotypic screening platform. iScience. 2023 Feb 17;26(2):105944. doi: 10.1016/j.isci.2023.105944. Epub 2023 Jan 7. PMID: 36644320; PMCID: PMC9822553.
  76. Gonther S, Bachmann M, Goren I, Huard A, Weigert A, Köhl J, Mühl H. 3'mRNA sequencing reveals pro-regenerative properties of c5ar1 during resolution of murine acetaminophen-induced liver injury. NPJ Regen Med. 2022 Jan 27;7(1):10. doi: 10.1038/s41536-022-00206-x. PMID: 35087052; PMCID: PMC8795215.
  77. Bojkova D, Zöller N, Tietgen M, Steinhorst K, Bechtel M, Rothenburger T, Kandler JD, Schneider J, Corman VM, Ciesek S, Rabenau HF, Wass MN, Kippenberger S, Göttig S, Michaelis M, Cinatl J Jr. Repurposing of the antibiotic nitroxoline for the treatment of mpox. J Med Virol. 2023 Mar;95(3):e28652. doi: 10.1002/jmv.28652. PMID: 36897017.
  78. Bojkova D, Bechtel M, Rothenburger T, Kandler JD, Hayes L, Olmer R, Martin U, Jonigk D, Ciesek S, Wass MN, Michaelis M, Cinatl J Jr. Omicron-induced interferon signaling prevents influenza A H1N1 and H5N1 virus infection. J Med Virol. 2023 Mar;95(3):e28686. doi: 10.1002/jmv.28686. PMID: 36938992.
  79. Huard A, Wilmes C, Kiprina A, Netzer C, Palmer G, Brüne B, Weigert A. Cell Intrinsic IL-38 Affects B Cell Differentiation and Antibody Production. Int J Mol Sci. 2023 Mar 16;24(6):5676. doi: 10.3390/ijms24065676. PMID: 36982750; PMCID: PMC10053218.

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