Publications

Within the GRK 2336, research projects study the cells and mediators involved in resolution-associated processes as well as the signaling cascades and target structures involved - with the aim of identifying alterations linked to dysregulated resolution of inflammation. Projects make use of primary human material, preclinically relevant animal models and cellular systems combined with biochemical, molecular biology, pharmacological and systems biology approaches. Especially in the last 3 years many findings within the research projects itself, in cooperation within the GRK and in cooperation with external partners have been published. The members of the GRK are highlighted in bold.

Publications in chronical order:

  1. Schierle S, Flauaus C, Heitel P, Willems S, Schmidt J, Kaiser A, Weizel L, Goebel T, Kahnt AS, Geisslinger G, Steinhilber D, Wurglics M, Rovati GE, Schmidtko A, Proschak E, Merk D. (2018) Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology. J Med Chem. 12;61(13):5758-5764. doi: 10.1021/acs.jmedchem.8b00458.
  2. Heitel P, Gellrich L, Heering J, Goebel T, Kahnt A, Proschak E, Schubert-Zsilavecz M, Merk D. (2018) Urate transporter inhibitor lesinurad is a selective peroxisome proliferator-activated receptor gamma modulator (sPPARγM) in vitro. Sci Rep. 8(1):13554. doi: 10.1038/s41598-018-31833-4.
  3. Winslow S, Scholz A, Rappl P, Brauß TF, Mertens C, Jung M, Weigert A, Brüne B, Schmid T (2019) Macrophages attenuate the transcription of CYP1A1 in breast tumor cells and enhance their proliferation. PLoS ONE 14,e0209694. doi: 10.1371/journal.pone.0209694.
  4. Wehbi B, Oblet C, Boyer F, Huard A, Druilhe A, Paraf F, Cogné E, Moreau J, El Makhour Y, Badran B, Van Egmond M, Cogné M, Aldigier JC. (2019) Mesangial Deposition Can Strongly Involve Innate-Like IgA Molecules Lacking Affinity Maturation. J Am Soc Nephrol. 30(7):1238-1249. doi: 10.1681/ASN.2018111089.
  5. Bräutigam J, Bischoff I, Schürmann C, Buchmann G, Epah J, Fuchs S, Heiss E, Brandes RP, Fürst R. (2019) Narciclasine inhibits angiogenic processes by activation of Rho kinase and by downregulation of the VEGF receptor 2. J Mol Cell Cardiol. Oct;135:97-108. doi: 10.1016/j.yjmcc.2019.08.001.
  6. Tarighi, N, Menger, D, Pierre, S, Kornstädt, L, Thomas, D, Ferreirós, N, Nüsing, RM, Geisslinger, G, Scholich, K (2019). Thromboxane-Induced α-CGRP Release from Peripheral Neurons Is an Essential Positive Feedback Loop in Capsaicin-Induced Neurogenic Inflammation. The Journal of Investigative Dermatology, 139(3), 656–664. doi.org/10.1016/j.jid.2018.10.01
  7. Syed SN, Raue R, Weigert A, von Knethen A, Brüne B. (2019) Macrophage S1PR1 Signaling Alters Angiogenesis and Lymphangiogenesis During Skin Inflammation. Cells. Jul 28;8(8):785. doi: 10.3390/cells8080785.
  8. Syed SN, Frank AC, Raue R, Brüne B. (2019) MicroRNA-A Tumor Trojan Horse for Tumor-Associated Macrophages. Cells. 21;8(12):1482. doi: 10.3390/cells8121482.
  9. Stark A, Schwenk R, Wack G, Zuchtriegel G, Hatemler MG, Bräutigam J, Schmidtko A, Reichel CA, Bischoff I, Fürst R (2019) Narciclasine exerts anti-inflammatory actions by blocking leukocyte-endothelial cell interactions and down-regulation of the endothelial TNF receptor 1. FASEB J. 33(8):8771-8781. doi: 10.1096/fj.201802440R.
  10. Göbel T, Diehl O, Heering J, Merk D, Angioni C, Wittmann SK, Buscato E, Kottke R, Weizel L, Schader T, Maier TJ, Geisslinger G, Schubert-Zsilavecz M, Steinhilber D, Proschak E, Kahnt AS (2019) 1Zafirlukast Is a Dual Modulator of Human Soluble Epoxide Hydrolase and Peroxisome Proliferator-Activated Receptor γ. Front Pharmacol. 0:263. doi: 10.3389/fphar.2019.00263.
  11. Schürmann C, Dienst FL, Pálfi K, Vasconez AE, Oo JA, Wang S, Buchmann GK, Offermanns S, van de Sluis B, Leisegang MS, Günther S, Humbert PO, Lee E, Zhu J, Weigert A, Mathoor P, Wittig I, Kruse C, Brandes RP (2019) The polarity protein Scrib limits atherosclerosis development in mice. Cardiovascular research. 115:1963–1974. doi: 10.1093/cvr/cvz093.
  12. Martin LM, Möller M, Weiss U, Russe OQ, Scholich K, Pierre S, Geisslinger G, Niederberger E (2019) 5-Amino-1-β-D-Ribofuranosyl-Imidazole-4-Carboxamide (AICAR) Reduces Peripheral Inflammation by Macrophage Phenotype Shift. Int J Mol Sci. 20(13):3255. doi: 10.3390/ijms20133255
  13. Han Y*, Mora J*, Huard A, da Silva P, Wiechmann S, Putyrski M, Schuster C, Elwakeel E, Lang G, Scholz A, Scholz T, Schmid T, de Bruin N, Billuart P, Sala C, Burkhardt H, Parnham MJ, Ernst A, Brüne B, Weigert A (2019) IL-38 Ameliorates Skin Inflammation and Limits IL-17 Production from γδ T Cells. Cell Rep. 27(3):835-846.e5. doi: 10.1016/j.celrep.2019.03.082. * contributed equally
  14. Gellrich L, Heitel P, Heering J, Kilu W, Pollinger J, Goebel T, Kahnt A, Arifi S, Pogoda W, Paulke A, Steinhilber D, Proschak E, Wurglics M, Schubert-Zsilavecz M, Chaikuad A, Knapp S, Bischoff I, Fürst R, Merk D (2020) l-Thyroxin and the Nonclassical Thyroid Hormone TETRAC Are Potent Activators of PPARγ. J Med Chem. 63(13):6727-6740. doi: 10.1021/acs.jmedchem.9b02150.
  15. Ebert R, Cumbana R, Lehmann C, Kutzner L, Toewe A, Ferreirós N, Parnham MJ, Schebb NH, Steinhilber D, Kahnt AS (2020) Long-term stimulation of toll-like receptor-2 and -4 upregulates 5-LO and 15-LO-2 expression thereby inducing a lipid mediator shift in human monocyte-derived macrophages. Biochim Biophys Acta Mol Cell Biol Lipids. 1865(9):158702. doi: 10.1016/j.bbalip.2020.158702.
  16. Cohnen, J, Kornstädt, L, Hahnefeld, L, Ferreiros, N, Pierre, S, Koehl, U, Deller, T, Geisslinger, G, Scholich, K (2020). Tumors Provoke Inflammation and Perineural Microlesions at Adjacent Peripheral Nerves. Cells. https://doi.org/10.3390/cells9020320
  17. Buchmann GK, Schürmann C, Warwick T, Schulz MH, Spaeth M, Müller OJ, Schröder K, Jo H, Weissmann N, Brandes RP (2020) Deletion of NoxO1 limits atherosclerosis development in female mice. Redox biology. 37:101713. doi: 10.1016/j.redox.2020.101713
  18. Wanior M, Preuss F, Ni X, Krämer A, Mathea S, Göbel T, Heidenreich D, Simonyi S, Kahnt AS, Joerger AC, Knapp S (2020) Pan-SMARCA/PB1 Bromodomain Inhibitors and Their Role in Regulating Adipogenesis. J Med Chem. 10;63(23):14680-14699. doi: 10.1021/acs.jmedchem.0c01242.
  19. von Hegedus JH, Kahnt AS, Ebert R, Heijink M, Toes REM, Giera M, Ioan-Facsinay A. (2020) Toll-like receptor signaling induces a temporal switch towards a resolving lipid profile in monocyte-derived macrophages. Biochim Biophys Acta Mol Cell Biol Lipids. 1865(9):158740. doi: 10.1016/j.bbalip.2020.158740.
  20. Sirait-Fischer E, Olesch C, Fink AF, Berkefeld M, Huard A, Schmid T, Takeda K, Brüne B, Weigert A (2020) Immune Checkpoint Blockade Improves Chemotherapy in the PyMT Mammary Carcinoma Mouse Model. Front. Oncol. 10;10:1771. doi: 10.3389/fonc.2020.01771.
  21. Seimetz M, Sommer N, Bednorz M, Pak O, Veith C, Hadzic S, Gredic M, Parajuli N, Kojonazarov B, Kraut S, Wilhelm J, Knoepp F, Henneke I, Pichl A, Kanbagli ZI, Scheibe S, Fysikopoulos A, Wu C-Y, Klepetko W, Jaksch P, Eichstaedt C, Grünig E, Hinderhofer K, Geiszt M, Müller N, Rezende F, Buchmann G, Wittig I, Hecker M, Hecker A, Padberg W, Dorfmüller P, Gattenlöhner S, Vogelmeier CF, Günther A, Karnati S, Baumgart-Vogt E, Schermuly RT, Ghofrani HA, Seeger W, Schröder K, Grimminger F, Brandes RP, Weissmann N. (2020) NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD. Nat Metab. 2:532–546. doi: 10.1038/s42255-020-0215-8. Erratum in: Nat Metab. 2(7):648.
  22. Scholz A, Rappl P, Böffinger N, Mota AC, Brüne B, Schmid T (2020) Translation of TNFAIP2 is tightly controlled by upstream open reading frames. Cell Mol Life Sci. 77, 2017-2027. doi: 10.1007/s00018-019-03265-4.
  23. Rehwald C, Schnetz M, Urbschat A, Mertens C, Meier JK, Bauer R, Baer P, Winslow S, Roos FC, Zwicker K, Huard A, Weigert A, Brüne B, Jung M. (2020) The iron load of lipocalin-2 (LCN-2) defines its pro-tumour function in clear-cell renal cell carcinoma. Br J Cancer. 122(3):421-433. doi: 10.1038/s41416-019-0655-7.
  24. Mosa, MH, Michels, BE, Menche, C, Nicolas, AM, Darvishi, T, Greten, FR, Farin, HF (2020). A Wnt-Induced Phenotypic Switch in Cancer-Associated Fibroblasts Inhibits EMT in Colorectal Cancer. Cancer Res. 80(24):5569-5582. doi: 10.1158/0008-5472.CAN-20-0263..
  25. Möller M, Wasel J, Schmetzer J, Weiß U, Meissner M, Schiffmann S, Weigert A, Möser CV, Niederberger E (2020) The Specific IKKε/TBK1 Inhibitor Amlexanox Suppresses Human Melanoma by the Inhibition of Autophagy, NF-κB and MAP Kinase Pathways. Int J Mol Sci. 21(13):4721. doi: 10.3390/ijms21134721
  26. Schuster C, Huard A, Sirait-Fischer E, Dillmann C, Brüne B, Weigert A (2020) S1PR4-dependent CCL2 production promotes macrophage recruitment in a murine psoriasis model. Eur J Immunol. 50(6):839-845. doi: 10.1002/eji.201948349.
  27. Varga J, Nicolas A, Petrocelli V, Pesic M, Mahmoud A, Michels BE, Etlioglu E, Yepes D, Häupl B, Ziegler PK, Bankov K, Wild PJ, Wanninger S, Medyouf H, Farin HF, Tejpar S, Oellerich T, Ruland J, Siebel CW, Greten FR (2020) AKT-dependent NOTCH3 activation drives tumor progression in a model of mesenchymal colorectal cancer. J Exp Med. Oct 5;217(10):e20191515. doi: 10.1084/jem.20191515. PMID: 32749453; PMCID: PMC7537393.
  28. Bachmann M, Lamprecht L, Gonther S, Pfeilschifter J, Mühl H. (2020) A murine cellular model of necroinflammation displays RAGE-dependent cytokine induction that connects to hepatoma cell injury. J Cell Mol Med. Sep;24(18):10356-10366. doi: 10.1111/jcmm.15649.
  29. Kesevan R, Frömel T, Zukunft S, Laban H, Geyer A, Naeem Z, Heidler J, Wittig I, Elwakeel E, Brüne B, Weigert A, Popp R, Fleming I (2020) Cyp2c44 regulates prostaglandin synthesis, lymphangiogenesis and metastasis in a mouse model of breast cancer. Proc Natl Acad Sci U S A. 117(11):5923-5930. doi: 10.1073/pnas.1921381117.
  30. Weiss, U, Möller, M, Husseini, SA, Manderscheid, C, Häusler, J, Geisslinger, G, Niederberger, E (2020). Inhibition of HDAC enzymes contributes to differential expression of pro-inflammatory proteins in the TLR-4 signaling cascade. Int J Mol Sci. 2020 Nov 25;21(23):8943. doi: 10.3390/ijms21238943.
  31. Han Y, Huard A, Mora J, da Silva P, Brüne B, Weigert A (2020) IL-36 family cytokines in protective versus destructive inflammation. Cell Signal. Nov;75:109773. doi: 10.1016/j.cellsig.2020.109773.
  32. Huard A*, Do H.N*, Hofmann M.C.J, Palmer G, Brüne B, de Bruin N, Weigert A (2021) IL-38 ablation reduces local inflammation and disease severity in experimental autoimmune encephalomyelitis. J Immunol. 206(5):1058-1066. doi: 10.4049/jimmunol.2000923. * contributed equally
  33. Hahnefeld, L*, Kornstädt, L*, Kratz, D, Ferreirós, N, Geisslinger, G, Pierre, S, Scholich, K (2021). Lipidomic analysis of local inflammation models shows a specific systemic acute phase response to lipopolysaccharides. Biochim Biophys Acta Mol Cell Biol Lipids., 1866(1), 158822. doi: 10.1016/j.bbalip.2020.158822. * contributed equally
  34. Rappl P, Rösser S, Maul P, Bauer R, Huard A, Schreiber Y, Thomas D, Geisslinger G, Jakobsson J, Weigert A, Brüne B, Schmid T. (2021) Inhibition of mPGES-1 attenuates efficient resolution of acute inflammation. Cell Death Dis. 12(2):135. doi: 10.1038/s41419-021-03423-2.
  35. Rappl P, Brüne B, Schmid T. (2021) Role of Tristetraprolin in the Resolution of Inflammation. Biology (Basel). 10(1):66. doi: 10.3390/biology10010066.
  36. Kornstädt, L, Pierre, S, Weigert, A, Ebersberger, S, Schäufele, TJ, Kolbinger, A, Schmid, T, Cohnen, J, Thomas, D, Ferreirós, N, Brüne, B, Ebersberger, I, Scholich, K (2021) Bacterial and fungal toll-like receptor activation elicits type I IFN responses in mast cells. Front. Immunol., 12 Feb. doi.org/10.3389/fimmu.2020.607048
  37. Knuth AK, Huard A, Naeem Z, Rappl P, Bauer R, Mota AC, Schmid T, Fleming I, Brüne B, Fulda S*, Weigert A*. (2021) Apoptotic Cells induce Proliferation of Peritoneal Macrophages. Int J Mol Sci. Feb 24;22(5):2230. doi: 10.3390/ijms22052230. PMID: 33668084; PMCID: PMC7956251. *Corresponding authors
  38. Krishnathas GM, Strödke B, Mittmann L, Zech T, Berger LM, Reichel CA, Rösser S, Schmid T, Knapp S, Müller S, Bracher F, Fürst R, Bischoff-Kont I. C81-evoked inhibition of the TNFR1-NFκB pathway during inflammatory processes for stabilization of the impaired vascular endothelial barrier for leukocytes. FASEB J. 2021 Jun;35(6):e21656. doi: 10.1096/fj.202100037R.