Latest News

New Publication – associate member Philipp Reus

We are happy to announce that our former PhD-student Philipp Reus associated to Project 12 (Denisa Bojkova) published further results of his work in the “Journal of controlled Release” with the title “Drug repurposing for the treatment of COVID-19: Targeting nafamostat to the lungs by a liposomal delivery system”.

Reference:

Reus P, Guthmann H, Uhlig N, Agbaria M, Issmail L, Eberlein V, Nordling-David MM, Jbara-Agbaria D, Ciesek S, Bojkova D, Cinatl J, Burger-Kentischer A, Rupp S, Zaliani A, Grunwald T, Gribbon P, Kannt A, Golomb G. Drug repurposing for the treatment of COVID-19: Targeting nafamostat to the lungs by a liposomal delivery system. J Control Release. 2023 Dec;364:654-671. doi: 10.1016/j.jconrel.2023.10.050. PMID: 37939853.

(members of the GRK are underlined)

New publication Project 6 and 1

Our former MD-student Pauline Hog published her work together with recent (Silvia Kuntschar) and former (Peter Rappl, Arnaud Huard) PhD students of project 6 (Bernhard brpne, Tobias Schmid) and project 1 (Andreas Weigert) in the Basel Journal “Biology” with the title “Prostaglandin E2 Boosts the Hyaluronan-Mediated Increase in Inflammatory Response to Lipopolysaccharide by Enhancing Lyve1 Expression”. Great joint success.

Reference:

Hog P, Kuntschar S, Rappl P, Huard A, Weigert A, Brüne B, Schmid T. Prostaglandin E2 Boosts the Hyaluronan-Mediated Increase in Inflammatory Response to Lipopolysaccharide by Enhancing Lyve1 Expression. Biology (Basel). 2023 Nov 16;12(11):1441. doi: 10.3390/biology12111441. PMID: 37998039; PMCID: PMC10669677.

(members of the GRK are underlined)

Invited talk - associate member Vanessa Maria Guerrero Ruiz

Vanessa Maria Guerrero Ruiz our associate member was invited to the INiBICA MEETING FOR YOUNG RESEARCHERS ABROAD (MYRA). INIBICA is the research institute associated to the university and hospital of Cadiz, and the aim of this small meeting is to invite young Spanish researchers abroad in order to promote networking. She gave a talk on 30th November. https://inibica.es/

New co-author publication project 7 – Joschua Friedel and Anja Kolbinger

Our PhD candidate Joschua Friedel and former associated member Anja Kolbinger are CoAuthors of a paper published by a fellow PhD candidate from the IRTG of the DFG-funded SFB 1039 in the “British Journal of Pharacology with the title “Meloxicam treatment disrupts the regional structure of innate inflammation sites by targeting the pro-inflammatory effects of prostanoids”.

Reference:

Schäufele TJ, Kolbinger A, Friedel J, Gurke R, Geisslinger G, Weigert A, Pierre S, Scholich K. Meloxicam treatment disrupts the regional structure of innate inflammation sites by targeting the pro-inflammatory effects of prostanoids. Br J Pharmacol. 2023 Oct 12. doi: 10.1111/bph.16261. Epub ahead of print. PMID: 37823675.

(members of the GRK are underlined)

New publication as co-author – associate member Camilla Tondello

Our former associated member Camilla Tondello is CoAuthor of a publication in the journal “Clinical and experimental Immunology” with the title “Combination treatment of a novel CXCR3 antagonist ACT-777991 with an anti-CD3 antibody synergistically increases persistent remission in experimental models of type 1 diabetes”.

Reference:

Christen U, Pouzol L, Tunis M, Sassi A, Tondello C, Bayer M, Hintermann E, Strasser DS, Schuldes S, Mentzel U, Martinic MM. Combination treatment of a novel CXCR3 antagonist ACT-777991 with an anti-CD3 antibody synergistically increases persistent remission in experimental models of type 1 diabetes. Clin Exp Immunol. 2023 Jul 17:uxad083. doi: 10.1093/cei/uxad083. PMID: 37458220.

(members of the GRK are underlined)

We are happy to announce a publication with several recent PhD (Sofie Meyer, Vanesa Maria Guerrero Ruiz, Silvia Rösser) former PhD (Rebecca Raue) and one of our recent MD-students (Milou Heffels) in the journal “Frontiers in Immunology” with the title “Hypoxia-altered cholesterol homeostasis enhances the expression of interferon-stimulated genes upon SARS-CoV-2 infections in monocytes.”. Great collaboration and great team work!

Reference:

Bauer R, Meyer SP, Raue R, Palmer MA, Guerrero Ruiz VM, Cardamone G, Rösser S, Heffels M, Roesmann F, Wilhelm A, Lütjohann D, Zarnack K, Fuhrmann DC, Widera M, Schmid T, Brüne B. Hypoxia-altered cholesterol homeostasis enhances the expression of interferon-stimulated genes upon SARS-CoV-2 infections in monocytes. Front Immunol. 2023 Jun 12;14:1121864. doi: 10.3389/fimmu.2023.1121864. PMID: 37377965; PMCID: PMC10291055.

(members of the GRK are underlined)

Invited talk – associate member Vanessa Maria Guerrero Ruiz

Vanessa Maria Guerrero Ruiz was invited to give a talk at the IBIS Wow Days! session. There, PhD students have to invite other Spanish scientists to give a talk at the Institute of Biomedicine of Sevilla (online).

Poster Prize “The EFIS-EJI Young Investigator Award” – Silvia Rösser and Vanessa Maria Guerrero Ruiz

Silvia Rösser and Vanessa Maria Guerrero Ruiz were awarded the “The EFIS-EJI Young Investigator Award" poster prize at the Meeting: 3rd Resolution Days in Besancon, France. Congratulation! Well-deserved!

New Publication – project 1

Results obtained in project 1 (PI Prof. A. Weigert) have been published by the former members A. Huard (PhD-student) and C. Wilmes (MD-student) together with the current PhD-student A. Kiprina under the title “Cell Intrinsic IL-38 Affects B Cell Differentiation and Antibody Production” in the International Journal of Molecular Sciences.

Reference:

Huard A, Wilmes C, Kiprina A, Netzer C, Palmer G, Brüne B, Weigert A. Cell Intrinsic IL-38 Affects B Cell Differentiation and Antibody Production. Int J Mol Sci. 2023 Mar 16;24(6):5676. doi: 10.3390/ijms24065676. PMID: 36982750; PMCID: PMC10053218.

(members of the GRK are underlined)

Two new Publication – project 12

Denisa Bojkova, PI of project 12 articles in the Journal of and supervisor of our member Joshua Kandler (PhD-student) successfully published with him as o-author two articles in the Journal of Medical Virology in March 23 with the titles “Omicron-induced interferon signaling prevents influenza A H1N1 and H5N1 virus infection” as well as “Repurposing of the antibiotic nitroxoline for the treatment of mpox”, repectivly.

Reference:

Bojkova D, Bechtel M, Rothenburger T, Kandler JD, Hayes L, Olmer R, Martin U, Jonigk D, Ciesek S, Wass MN, Michaelis M, Cinatl J Jr. Omicron-induced interferon signaling prevents influenza A H1N1 and H5N1 virus infection. J Med Virol. 2023 Mar;95(3):e28686. doi: 10.1002/jmv.28686. PMID: 36938992.

Bojkova D, Zöller N, Tietgen M, Steinhorst K, Bechtel M, Rothenburger T, Kandler JD, Schneider J, Corman VM, Ciesek S, Rabenau HF, Wass MN, Kippenberger S, Göttig S, Michaelis M, Cinatl J Jr. Repurposing of the antibiotic nitroxoline for the treatment of mpox. J Med Virol. 2023 Mar;95(3):e28652. doi: 10.1002/jmv.28652. PMID: 36897017.

(members of the GRK are underlined)

New Publication –projects 3 in cooperation with project 1

We are happy to announce that our former PhD-student of project 3 (PI: H. Mühl) Sina Gonter published further results of her work in collaboration with project 1 (A. Huard and PI: A. Weigert) in the nature partner journal Regenerative medicine with the title “3'mRNA sequencing reveals pro-regenerative properties of c5ar1 during resolution of murine acetaminophen-induced liver injury”.

Reference:

Gonther S, Bachmann M, Goren I, Huard A, Weigert A, Köhl J, Mühl H. 3'mRNA sequencing reveals pro-regenerative properties of c5ar1 during resolution of murine acetaminophen-induced liver injury. NPJ Regen Med. 2022 Jan 27;7(1):10. doi: 10.1038/s41536-022-00206-x. PMID: 35087052; PMCID: PMC8795215.

(members of the GRK are underlined)

New Publication – project 12

Denisa Bojkova, PI of project 12 and supervisor of our members Joshua Kandler (PhD-student), Philipp Reus (PhD-student) and Leona Panosh (MD-student) published together with them and others her work on “Identification of novel antiviral drug candidates using an optimized SARS-CoV-2 phenotypic screening platform” in the Journal of iScience (Cell Press).

Reference:

Bojkova D, Reus P, Panosch L, Bechtel M, Rothenburger T, Kandler JD, Pfeiffer A, Wagner JUG, Shumliakivska M, Dimmeler S, Olmer R, Martin U, Vondran FWR, Toptan T, Rothweiler F, Zehner R, Rabenau HF, Osman KL, Pullan ST, Carroll MW, Stack R, Ciesek S, Wass MN, Michaelis M, Cinatl J Jr. Identification of novel antiviral drug candidates using an optimized SARS-CoV-2 phenotypic screening platform. iScience. 2023 Feb 17;26(2):105944. doi: 10.1016/j.isci.2023.105944. Epub 2023 Jan 7. PMID: 36644320; PMCID: PMC9822553.

(members of the GRK are underlined)

New publication – project 7 Anja Kolbinger and Joschua Friedel

Anja Kolbinger our associate member published together with Joschua Friedel the current PhD-student of project 7 and others parts her work with the title “Eosinophil-derived IL-4 is necessary to establish the inflammatory structure in innate inflammation” in the EMBO press Journal Molecular Medicine. Congratulation.

Reference:

Kolbinger A, Schäufele TJ, Steigerwald H, Friedel J, Pierre S, Geisslinger G, Scholich K. Eosinophil-derived IL-4 is necessary to establish the inflammatory structure in innate inflammation. EMBO Mol Med. 2022 Dec 21:e16796. doi: 10.15252/emmm.202216796. Epub ahead of print. PMID: 36541656.

(members of the GRK are underlined)

New publication – former member Adele Nicholas

Our former PhD-stdeunt Adele Nicolas published parts of her current work with the title “Image-guided radiotherapy in an orthotopic mouse model of rectal cancer” in the Journal STAR protocols.

Reference:

Nicolas AM, Pesic M, Rödel F, Fokas E, Greten FR. Image-guided radiotherapy in an orthotopic mouse model of rectal cancer. STAR Protoc. 2022 Dec 16;3(4):101749. doi: 10.1016/j.xpro.2022.101749. Epub 2022 Oct 5. PMID: 36206161; PMCID: PMC9547293.

(members of the GRK are underlined)

New publication in cooperation of four GRK PIs and our Swedish collaboration partners

Our former associate member Tamara Göbel as well as four GRK-PIs (Steinhilber, Schmid, Fürst, Brandes) and our Swedish partners and others collaborated for the publication of M. Kreiß in the journal of Biochemical Pharmacology with the title “Human 5-lipoxygenase regulates transcription by association to euchromatin”.

Reference:

Kreiß M, Oberlis JH, Seuter S, Bischoff-Kont I, Sürün D, Thomas D, Göbel T, Schmid T, Rådmark O, Brandes RP, Fürst R, Häfner AK, Steinhilber D. Human 5-lipoxygenase regulates transcription by association to euchromatin. Biochem Pharmacol. 2022 Sep;203:115187. doi: 10.1016/j.bcp.2022.115187. Epub 2022 Jul 22. PMID: 35878796.

(members of the GRK are underlined)

New publication – graduate student Zumer Naeem

We are happy to announce that our former PhD-student Zumer Naeem published parts of her current work in the Journal Pfugers Archiv European Journal of Physiology with the title “Role of the soluble epoxide hydrolase in the hair follicle stem cell homeostasis and hair growth”.

Reference:

Naeem Z, Zukunft S, Günther S, Liebner S, Weigert A, Hammock BD, Frömel T, Fleming I. Role of the soluble epoxide hydrolase in the hair follicle stem cell homeostasis and hair growth. Pflugers Arch. 2022 Sep;474(9):1021-1035. doi: 10.1007/s00424-022-02709-4. PMID: 35648219; PMCID: PMC9393123.

(members of the GRK are underlined)

New publication – graduate student Sarah Ciurus

Our student Sarah Ciurus/ project 9 is co-author of a work published by members of the group of Prof. Robert Fürst PI of project 9 and other collaboration partners.

Reference:

Burgers LD, Li Y, Michalakis S, Ciurus S, Zahler S, Müller R, Fürst R. The protein biosynthesis inhibitor vioprolide A evokes anti-angiogenic and pro-survival actions by targeting NOP14 and decreasing VEGF receptor 2- and TAZ-signaling. Biomed Pharmacother. 2022 Aug;152:113174. doi: 10.1016/j.biopha.2022.113174. Epub 2022 Jun 2. PMID: 35665668.

(members of the GRK are underlined)

New publication – graduate student Ürün Ukan

Our PhD candidate Ürün Ukan working in project 6 (PI: Prof. Ingrid Fleming) published parts of her work in the Journal Cells under the title “Effect of Thrombin on the Metabolism and Function of Murine Macrophages.” Congratulation!

Reference:

Ukan Ü, Delgado Lagos F, Kempf S, Günther S, Siragusa M, Fisslthaler B, Fleming I. Effect of Thrombin on the Metabolism and Function of Murine Macrophages. Cells. 2022 May 23;11(10):1718. doi: 10.3390/cells11101718. PMID: 35626753; PMCID: PMC9139186.

(members of the GRK are underlined)

New publication – associate member Anja Kolbinger

We are happy to announce that our associate PhD-student Anja Kolbinger (PI: Klaus Scholich project 7) published parts of her work in the Journal Cells with the title “Behind the Wall-Compartment-Specific Neovascularisation during Post-Stroke Recovery in Mice”. Congratulation! We don’t want to miss to mention, that the work is done in close cooperation with project B08 of the SFB 1039, our yearly summer school partner.

Reference:

Kolbinger A, Kestner RI, Jencio L, Schäufele TJ, Vutukuri R, Pfeilschifter W, Scholich K. Behind the Wall-Compartment-Specific Neovascularisation during Post-Stroke Recovery in Mice. Cells. 2022 May 17;11(10):1659. doi: 10.3390/cells11101659. PMID: 35626695; PMCID: PMC9139871.

(members of the GRK are underlined)

New publication/ co-authorships – project 4

Our former PhD-student Roland Ebert and our former associate member Tamara Göbel as well as the current GRK PhD students Andre Krommes from project 4 are co-authors of a work published together with the PIs of project 4 Prof. Steinhilber and Dr. Kahnt (last authorship) and others. Our PI of project 1, Prof. Andreas Weigert, is also co-author of this publication.

Reference:

Mainka M, George S, Angioni C, Ebert R, Goebel T, Kampschulte N, Krommes A, Weigert A, Thomas D, Schebb NH, Steinhilber D, Kahnt AS. On the biosynthesis of specialized pro-resolving mediators in human neutrophils and the influence of cell integrity. Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Mar;1867(3):159093. doi: 10.1016/j.bbalip.2021.159093. Epub 2021 Dec 21. PMID: 34942381.

(members of the GRK are underlined)

New publication associate member Rebecca Raue – cluster 2

Our associate PhD-student Rebecca Raue recently published her work in the Journal Biology (Basel) with the title “MicroRNA-200c Attenuates the Tumor-Infiltrating Capacity of Macrophages” in cooperation with the current PhD-student Silvia Rösser of project 6, PIs of the GRK (project1 and 6) and others. Good work!

Reference:

Raue R, Frank AC, Fuhrmann DC, de la Cruz-Ojeda P, Rösser S, Bauer R, Cardamone G, Weigert A, Syed SN, Schmid T, Brüne B. MicroRNA-200c Attenuates the Tumor-Infiltrating Capacity of Macrophages. Biology (Basel). 2022 Feb 22;11(3):349. doi: 10.3390/biology11030349. PMID: 35336722

(members of the GRK are underlined)

New Publication Project 11 / Cover Article – Adele Nicolas

Our former student Adele Nicolas/ project 11 published her work as first author in the journal Cancer Cell with the title “Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer”. Congratulations for this great success! CoAuthors are besides others the current student in project 11/ Kilian Kennel and Andreas Weigert PI of project 1. Congratulation to everybody for this great work which in addition was selected as cover article in February 2022 (https://www.cell.com/cancer-cell/issue?pii=S1535-6108(21)X0003-7)!

Reference:

Nicolas AM, Pesic M, Engel E, Ziegler PK, Diefenhardt M, Kennel KB, Buettner F, Conche C, Petrocelli V, Elwakeel E, Weigert A, Zinoveva A, Fleischmann M, Häupl B, Karakütük C, Bohnenberger H, Mosa MH, Kaderali L, Gaedcke J, Ghadimi M, Rödel F, Arkan MC, Oellerich T, Rödel C, Fokas E, Greten FR. Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer. Cancer Cell. 2022 Feb 14;40(2):168-184.e13. doi: 10.1016/j.ccell.2022.01.004. Epub 2022 Feb 3. PMID: 35120600.

(members of the GRK are underlined)

New Publication Project 3 – Sina Gonther

We are happy to announce that our former PhD-student Sina Gonther of a work published parts of her work on her GRK-project “Termination of necroinflammation mediating recovery from paracetamol induced liver injury” in the Journal Nature Partner Journal Regenerative Medicine with the title “3’mRNA sequencing reveals pro-regenerative properties of c5ar1 during resolution of murine acetaminophen-induced liver injury.” The work was performed in collaboration with the GRK project 01 (former PhD-student Arnaud Huard and the PI Andreas Weigert as Co-authors). Congratulations!

Reference:

Gonther S, Bachmann M, Goren I,Huard A, Weigert A, Köhl J and Mühl H. 3’mRNA sequencing reveals pro-regenerative properties of c5ar1 during resolution of murine acetaminophen-induced liver injury. NPJ Regen Med, 2022 (in press).

(members of the GRK are underlined)

Successful application – Second 4,5 year funding of the DFG until September 2026 granted.

Today, the DFG has officially announced the successful prolongation of our GRK. Many thanks to the DFG for 4,5 year of additional funding and also many thanks to all current and former members of the GRK 2336, especially our highly motivated current and former students for their work and dedication that made this success possible.

New Publication Project 12

Our students Joshua Kandler and Philipp Reus are co-authors (besides others) of a work published by Prof. Bojkova (project leader project 12) in shared first authorship together with Katie-May McLaughlin from the University of Kent. Additional co-author is our PI of project 1 Prof. Andreas Weigert. Again showing a good collaboration between the projects. Congrats!

Reference:

McLaughlin* K-M, Bojkova* D, Kandler* JD, Bechtel M, Reus P, Le T, Rothweiler F, Wagner JUG, Weigert A, Ciesek S, Wass MN, Michaelis M, Cinatl J (2021) A Potential Role of the CD47/SIRPalpha Axis in COVID-19 Pathogenesis. Curr. Issues Mol. Biol. 2021, 43, 1212–1225. doi:10.3390/cimb43030086 *contributed equally

(members of the GRK are underlined)

New Publication - Associate member Hendrik Stülb

Our associated PhD-student Hendrik Stülb working in the group of Prof. Heiko Mühl (project 3) published his work under the title “Acetaminophen-induced liver injury exposes murine IL-22 as 2 sex-related gene product” in the International Journal of Molecular Sciences. It is important to note that the CoAuthor Sina Gonther is the former PhD student (first cohort)

Reference:

Hendrik Stülb, Malte Bachmann, Sina Gonther and Heiko Mühl (2021) "Acetaminophen-induced liver injury exposes murine IL-22 as 2 sex-related gene product", International Journal of Molecular Sciences, accepted for publication

(members of the GRK are underlined)

New Publication Project 10 - Giulia Buchmann

We are happy to announce that our former PhD-student of project 10 (Prof. Brandes) Giulia Buchmann published again in the Journal Redox Biology. A publication with the title “The hydrogen-peroxide producing NADPH oxidase 4 does not limit neointima development after vascular injury in mice”. Congratulation!

Reference:

Buchmann GK, Schürmann C, Spaeth M, Abplanalp W, Tombor L, John D, Warwick T, Rezende F, Weigert A, Shah AM, Hansmann ML, Weissmann N, Dimmeler S, Schröder K, Brandes RP. The hydrogen-peroxide producing NADPH oxidase 4 does not limit neointima development after vascular injury in mice. Redox Biol. 2021 Sep;45:102050. doi: 10.1016/j.redox.2021.102050. Epub 2021 Jun 18. PMID: 34218201; PMCID: PMC8256285.

(members of the GRK are underlined)

Next Career step – Sina Gonther

Recently, our former PhD candidate joined the lab of Prof. Sadik, Department of Dermatology as postdoc. The group is investigates chronic-inflammatory skin diseases. Best of wishes!

Next career step – Giulia Buchmann

Our former PhD-candidate Giulia Buchmann joins the lab of Prof. Ralf Brandes, Institute of Cardiovascular Physiology and PI of project 10 as postdoc. Best of wishes!

Next Career Step – Arnaud Huard

Our former PhD-candidate Arnaud Huard takes up a job as postdoc in the group of Dr. Gaby Palmer at the Department of Pathology and Immunology at the Centre Medical Universitaire, Geneva. Best of wishes!

Next Career Step – Lisa Kornstädt

Our former PhD-candidate Lisa Kornstädt joins the company BioSpring GmbH in Frankfurt as junior project manager in the nucleic acid production. Best of wishes!

New Publication Project 9 – Melissa Krishnathas

We are happy to announce that our former PhD-student Melissa Krishnathas published parts of her work of project 9 “The pharmacological inhibition of the BMP-2-inducible kinase for the resolution of inflammation” (Prof. Robert Fürst) in the FASEB Journal with the title “C81-evoked inhibition of the TNFR1-NFκB pathway during inflammatory processes for stabilization of the impaired vascular endothelial barrier for leukocytes”. Our associate student Thomas Zech (project 9) as well as our PhD student Silvia Rösser and one of her supervisors PD Dr. Tobias Schmid (project 6) are CoAuthors of this publication. Again stating the fruitful cooperation within the GRK. Congratulation!

Reference:

Krishnathas GM, Strödke B, Mittmann L, Zech T, Berger LM, Reichel CA, Rösser S, Schmid T, Knapp S, Müller S, Bracher F, Fürst R, Bischoff-Kont I. C81-evoked inhibition of the TNFR1-NFκB pathway during inflammatory processes for stabilization of the impaired vascular endothelial barrier for leukocytes. FASEB J. 2021 Jun;35(6):e21656. doi: 10.1096/fj.202100037R.

(members of the GRK are underlined)

Next career step - Peter Rappl

Our former PhD-candidate Peter Rappl joins the company Biovis Diagnostik MVZ GmbH as R&D scientist in the immunology division. Best of wishes!

Two newly appointed Prof. within the GRK

Congratulation to our PI Denisa Bojkova (project 2) to be awarded with the Professorship (W1, founded by the Stefan Quandt foundation for 5 years) in Virology with the focus on corona viruses at the Institute of Medical Virology (Prof. Sandra Ciesek).

Congratulation also to our PI Andreas Weigert (project 1) for gaining the Professorship (W2) for Biochemistry of Innate immunology at the Institute of Biochemistry 1 (Prof. Bernhard Brüne).

Great success!

New Publication Project 2 - Anne-Kathrin Knut

Parts of the work of our PhD-student Anne-Kathrin Knut on “The role of necroptosis versus apoptosis in the resolution of inflammation” (project 2, Prof. Simone Fulda) with the title “Apoptotic Cells induce Proliferation of Peritoneal Macrophages” is accepted for publication in the International Journal of Molecular Sciences. Congratulation! It is important to note that in addition three other GRK-projects were involved (Project 1, Project 5 and Project 6) making it a very good example of the fruitful cooperation within the GRK.

Reference:

Knuth AK, Huard A, Naeem Z, Rappl P, Bauer R, Mota AC, Schmid T, Fleming I, Brüne B, Fulda S, Weigert A. Apoptotic Cells induce Proliferation of Peritoneal Macrophages. Int J Mol Sci. 2021 Feb 24;22(5):2230. doi: 10.3390/ijms22052230. PMID: 33668084; PMCID: PMC7956251.

(members of the GRK are underlined)

New Publication Project 1 - Arnaud Huard & Nam Do

Our PhD candidate Arnaud Huard and our MD student Nam Do published their work on IL38 (project 1, PD Dr. Andreas Weigert) in the Journal of Immunology under the title “IL-38 ablation reduces local inflammation and disease severity in experimental autoimmune encephalomyelitis.” Congratulation!

Reference:

Huard A*, Do H.N*, Hofmann M.C.J, Palmer G, Brüne B, de Bruin N, Weigert A (2021) IL-38 ablation reduces local inflammation and disease severity in experimental autoimmune encephalomyelitis. J Immunol. 206(5):1058-1066. doi: 10.4049/jimmunol.2000923.

New Publication Project 6 - Review Peter Rappl

After publishing his scientific work just recently our student member Peter Rappl published a review on “Role of Tristetraprolin in the Resolution of Inflammation” as first author in the journal Biology (Basel). Congratulation!

Reference:

Rappl P, Brüne B, Schmid T. (2021) Role of Tristetraprolin in the Resolution of Inflammation. Biology (Basel). 10(1):66. doi: 10.3390/biology10010066.

(members of the GRK are underlined)

New Publication Project 6 - Peter Rappl

Our PhD-student Peter Rappl working on “mPEGES-1 in macrophages during resolution of inflammation” (Prof. Bernhard Brüne, PD Dr. Tobias Schmid) published his work under the title “Inhibition of mPGES-1 attenuates efficient resolution of acute inflammation.” in the journal Cell Death and Disease. It is important to note that the CoAuthor Sylvia Rösser followed Peter Rappl as PhD candidate in project 6 and Patrick Maul successfully performed his MD thesis in the GRK. Members of project 1 are also involved. Congratulations to all.

Reference:

Rappl P, Rösser S, Maul P, Bauer R, Huard A, Schreiber Y, Thomas D, Geisslinger G, Jakobsson J, Weigert A, Brüne B, Schmid T. (2021) Inhibition of mPGES-1 attenuates efficient resolution of acute inflammation. Cell Death Dis. 12(2):135. doi: 10.1038/s41419-021-03423-2.

(members of the GRK are underlined)

New Publication Project 7 - Lisa Kornstädt

Lisa Kornstädt, PhD-student in project 8 (Prof. Klaus Scholich) published her work on “Bacterial and Fungal Toll-Like Receptor Activation Elicits Type I IFN Responses in Mast Cells” in the Journal Frontiers in Immunology. The work was accepted for publication end of December 2020. Again other PIs of our GRK were involved (PD. Dr. Weigert/ project 1, PD Dr. Tobias Schmid and Prof. Bernhard Brüne/ project 6) stating the good cooperation within the GRK.

Reference:

Kornstädt, L., Pierre, S., Weigert, A., Ebersberger, S., Schäufele, T. J., Kolbinger, A., Schmid, T., Cohnen, J., Brüne, B., Ebersberger, I., Thomas, D., Ferreiro, N., & Scholich, K. Bacterial and Fungal Toll-Like Receptor Activation Elicits Type I IFN Responses in Mast Cells. Frontiers in Immunology. 2021. Dec29:11, 3872. doi:10.3389/fimmu.2020.607048

(members of the GRK are underlined)

Arnaud Huard and Roland Ebert awarded with a 6-month scholarship

The GRK offers the possibility to apply for a 6-month postdoc scholarship paid by the GRK. To apply for this short-term funding the applicant has to plan a postdoc position out of Germany (letter of intent of the receiving institute) which is funded by a self-raised funding (planned). Both candidates fulfilled these requirements and have now time to finish and submit their applications. Best of luck!

New Publication Project - Ulrike Weiss

We are happy to announce that our PhD-student Ulrike Weiss published parts of her work of project 8 “The Role of IKKε in the resolution of inflammation in atherosclerosis” (Prof. Ellen Niederberger) in the International Journal of Molecular Sciences with the title “Inhibition of HDAC enzymes contributes to differential expression of pro-inflammatory proteins in the TLR-4 signaling cascade”. Our MD student Sayed Adham Husseini is CoAuthor of this publication. Congratulation!

Reference:

Weiss, U., Möller, M., Husseini, S. A., Manderscheid, C., Häusler, J., Geisslinger, G., Niederberger, E. (2020). Inhibition of HDAC enzymes contributes to differential expression of pro-inflammatory proteins in the TLR-4 signaling cascade. Int J Mol Sci. 2020 Nov 25;21(23):8943. doi: 10.3390/ijms21238943.

(members of the GRK are underlined)

Warm welcome to our New Project 12 - Dr. Denisa Bojkova

With the new project “SARS-CoV-2 infections in Monocytes/ Macrophages: inflammation patterns and resolution of inflammation” under the supervision of Dr. Denisa Bojkova (Institute of Medical Virology, University Clinic Frankfurt) the GRK was able to recruit a successful young academic working on a contemporary scientific project. The project was evaluated by the DFG and external reviewers and officially affiliated to the GRK as project 12 within the cluster 2.

New Publication Project 7 - Lisa Kornstädt

In cooperation with her coworker Lisa Hahnefeld our student Lisa Kornstädt (shared first authorship) published parts of her work on “Regulation of resolution of inflammation by mast cells” (project 7/ Prof. Klaus Scholich) in the Journal Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids under the title “Lipidomic analysis of local inflammation models shows a specific systemic acute phase response to lipopolysaccharides”. Congratulation to this success!

Reference:

Hahnefeld, L.*, Kornstädt, L.*, Kratz, D., Ferreirós, N., Geisslinger, G., Pierre, S., & Scholich, K. Lipidomic analysis of local inflammation models shows a specific systemic acute phase response to lipopolysaccharides. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 2021 Sep23; 1866(1), 158822. doi: 10.1016/j.bbalip.2020.158822 * equally contributed.

(members of the GRK are underlined)

New Publication Project 10 - Giulia Buchmann

We are happy to announce that our PhD-student Giulia Buchmann published parts of her work of project 10 “Role of the NADPH Oxidase NOX4 in the termination of vascular inflammatory reaction after vascular injury” (Prof. Ralf Brandes) in the journal Redox Biology with the title “Deletion of NoxO1 limits atherosclerosis development in female mice. Redox biology”. Congratulation.

Reference:

Buchmann GK, Schürmann C, Warwick T, Schulz MH, Spaeth M, Müller OJ, Schröder K, Jo H, Weissmann N, Brandes RP. (2020) Deletion of NoxO1 limits atherosclerosis development in female mice. Redox biology. 37:101713. doi: 10.1016/j.redox.2020.101713.

(members of the GRK are underlined)

Recruitment of the new cohort completed

We are happy to announce that we found 10 promising PhD candidates for the second 3-years turnus of our training program. More information will follow soon.

Prof. Fulda was elected president of the Christian-Albrechts-Universits Kiel

Congratulations to Prof. Fulda (PI project 2) for her election as president of the Christian Albrechts University Kiel. We are sad that she leaves the GRK and project 2 will end with her job change in October, but are certain she will master her new duties very successfully. Congratulation!

Application window opens today!

Starting October 1st, 2020 we offer 11 PhD student positions within the doctoral program GRK 2336 „Resolution of inflammation – mediators, signaling and intervention“ - go to Application (https://www.grk-ave.de/application/) for more details. Application deadline ends June 30th, 2020.

New Publication Project 4 - Roland Ebert

Our student Roland Ebert published his work within the GRK project 4 “5-/15-Lipoxigenase interaction as regulatory principle in the lipoxin synthesis during resolution of inflammation” (Prof. Dieter Steinhilber) under the title “Long-term stimulation of toll-like receptor-2 and -4 upregulates 5-LO and 15-LO-2 expression thereby inducing a lipid mediator shift in human monocyte-derived macrophages.” in the journal Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. Congratulation.

Reference:

Ebert R, Cumbana R, Lehmann C, Kutzner L, Toewe A, Ferreirós N, Parnham MJ, Schebb NH, Steinhilber D, Kahnt AS. (2020) Long-term stimulation of toll-like receptor-2 and -4 upregulates 5-LO and 15-LO-2 expression thereby inducing a lipid mediator shift in human monocyte-derived macrophages. Biochim Biophys Acta Mol Cell Biol Lipids. 1865(9):158702. doi: 10.1016/j.bbalip.2020.158702.

(members of the GRK are underlined)