Latest News

15.07.2021

New Publication Project 10 - Giulia Buchmann

We are happy to announce that our former PhD-student of project 10 (Prof. Brandes) Giulia Buchmann published again in the Journal Redox Biology. A publication with the title “The hydrogen-peroxide producing NADPH oxidase 4 does not limit neointima development after vascular injury in mice”. Congratulation!

Reference:

Buchmann GK, Schürmann C, Spaeth M, Abplanalp W, Tombor L, John D, Warwick T, Rezende F, Weigert A, Shah AM, Hansmann ML, Weissmann N, Dimmeler S, Schröder K, Brandes RP. The hydrogen-peroxide producing NADPH oxidase 4 does not limit neointima development after vascular injury in mice. Redox Biol. 2021 Sep;45:102050. doi: 10.1016/j.redox.2021.102050. Epub 2021 Jun 18. PMID: 34218201; PMCID: PMC8256285.

(members of the GRK are underlined)

10.07.2021

Next Career step – Sina Gonther

Recently, our former PhD candidate joined the lab of Prof. Sadik, Department of Dermatology as postdoc. The group is investigates chronic-inflammatory skin diseases. Best of wishes!

01.07.2021

Next career step – Giulia Buchmann

Our former PhD-candidate Giulia Buchmann joins the lab of Prof. Ralf Brandes, Institute of Cardiovascular Physiology and PI of project 10 as postdoc. Best of wishes!

01.07.2021

Next Career Step – Arnaud Huard

Our former PhD-candidate Arnaud Huard takes up a job as postdoc in the group of Dr. Gaby Palmer at the Department of Pathology and Immunology at the Centre Medical Universitaire, Geneva. Best of wishes!

15.05.2021

Next Career Step – Lisa Kornstädt

Our former PhD-candidate Lisa Kornstädt joins the company BioSpring GmbH in Frankfurt as junior project manager in the nucleic acid production. Best of wishes!

24.04.2021

New Publication Project 9 – Melissa Krishnathas

We are happy to announce that our former PhD-student Melissa Krishnathas published parts of her work of project 9 “The pharmacological inhibition of the BMP-2-inducible kinase for the resolution of inflammation” (Prof. Robert Fürst) in the FASEB Journal with the title “C81-evoked inhibition of the TNFR1-NFκB pathway during inflammatory processes for stabilization of the impaired vascular endothelial barrier for leukocytes”. Our associate student Thomas Zech (project 9) as well as our PhD student Silvia Rösser and one of her supervisors PD Dr. Tobias Schmid (project 6) are CoAuthors of this publication. Again stating the fruitful cooperation within the GRK. Congratulation!

Reference:

Krishnathas GM, Strödke B, Mittmann L, Zech T, Berger LM, Reichel CA, Rösser S, Schmid T, Knapp S, Müller S, Bracher F, Fürst R, Bischoff-Kont I. C81-evoked inhibition of the TNFR1-NFκB pathway during inflammatory processes for stabilization of the impaired vascular endothelial barrier for leukocytes. FASEB J. 2021 Jun;35(6):e21656. doi: 10.1096/fj.202100037R.

(members of the GRK are underlined)

12.04.2021

Next career step - Peter Rappl

Our former PhD-candidate Peter Rappl joins the company Biovis Diagnostik MVZ GmbH as R&D scientist in the immunology division. Best of wishes!

11.03.2021

Two newly appointed Prof. within the GRK

Congratulation to our PI Denisa Bojkova (project 2) to be awarded with the Professorship (W1, founded by the Stefan Quandt foundation for 5 years) in Virology with the focus on corona viruses at the Institute of Medical Virology (Prof. Sandra Ciesek).

Congratulation also to our PI Andreas Weigert (project 1) for gaining the Professorship (W2) for Biochemistry of Innate immunology at the Institute of Biochemistry 1 (Prof. Bernhard Brüne).

Great success!

22.02.2021

New Publication Project 2 - Anne-Kathrin Knut

Parts of the work of our PhD-student Anne-Kathrin Knut on “The role of necroptosis versus apoptosis in the resolution of inflammation” (project 2, Prof. Simone Fulda) with the title “Apoptotic Cells induce Proliferation of Peritoneal Macrophages” is accepted for publication in the International Journal of Molecular Sciences. Congratulation! It is important to note that in addition three other GRK-projects were involved (Project 1, Project 5 and Project 6) making it a very good example of the fruitful cooperation within the GRK.

Reference:

Knuth AK, Huard A, Naeem Z, Rappl P, Bauer R, Mota AC, Schmid T, Fleming I, Brüne B, Fulda S, Weigert A. Apoptotic Cells induce Proliferation of Peritoneal Macrophages. Int J Mol Sci. 2021 Feb 24;22(5):2230. doi: 10.3390/ijms22052230. PMID: 33668084; PMCID: PMC7956251.

(members of the GRK are underlined)

08.02.2021

New Publication Project 1 - Arnaud Huard & Nam Do

Our PhD candidate Arnaud Huard and our MD student Nam Do published their work on IL38 (project 1, PD Dr. Andreas Weigert) in the Journal of Immunology under the title “IL-38 ablation reduces local inflammation and disease severity in experimental autoimmune encephalomyelitis.” Congratulation!

Reference:

Huard A*, Do H.N*, Hofmann M.C.J, Palmer G, Brüne B, de Bruin N, Weigert A (2021) IL-38 ablation reduces local inflammation and disease severity in experimental autoimmune encephalomyelitis. J Immunol. 206(5):1058-1066. doi: 10.4049/jimmunol.2000923.

22.01.2021

New Publication Project 6 - Review Peter Rappl

After publishing his scientific work just recently our student member Peter Rappl published a review on “Role of Tristetraprolin in the Resolution of Inflammation” as first author in the journal Biology (Basel). Congratulation!

Reference:

Rappl P, Brüne B, Schmid T. (2021) Role of Tristetraprolin in the Resolution of Inflammation. Biology (Basel). 10(1):66. doi: 10.3390/biology10010066.

(members of the GRK are underlined)

11.01.2021

New Publication Project 6 - Peter Rappl

Our PhD-student Peter Rappl working on “mPEGES-1 in macrophages during resolution of inflammation” (Prof. Bernhard Brüne, PD Dr. Tobias Schmid) published his work under the title “Inhibition of mPGES-1 attenuates efficient resolution of acute inflammation.” in the journal Cell Death and Disease. It is important to note that the CoAuthor Sylvia Rösser followed Peter Rappl as PhD candidate in project 6 and Patrick Maul successfully performed his MD thesis in the GRK. Members of project 1 are also involved. Congratulations to all.

Reference:

Rappl P, Rösser S, Maul P, Bauer R, Huard A, Schreiber Y, Thomas D, Geisslinger G, Jakobsson J, Weigert A, Brüne B, Schmid T. (2021) Inhibition of mPGES-1 attenuates efficient resolution of acute inflammation. Cell Death Dis. 12(2):135. doi: 10.1038/s41419-021-03423-2.

(members of the GRK are underlined)

05.01.2021

New Publication Project 7 - Lisa Kornstädt

Lisa Kornstädt, PhD-student in project 8 (Prof. Klaus Scholich) published her work on “Bacterial and Fungal Toll-Like Receptor Activation Elicits Type I IFN Responses in Mast Cells” in the Journal Frontiers in Immunology. The work was accepted for publication end of December 2020. Again other PIs of our GRK were involved (PD. Dr. Weigert/ project 1, PD Dr. Tobias Schmid and Prof. Bernhard Brüne/ project 6) stating the good cooperation within the GRK.

Reference:

Kornstädt, L., Pierre, S., Weigert, A., Ebersberger, S., Schäufele, T. J., Kolbinger, A., Schmid, T., Cohnen, J., Brüne, B., Ebersberger, I., Thomas, D., Ferreiro, N., & Scholich, K. Bacterial and Fungal Toll-Like Receptor Activation Elicits Type I IFN Responses in Mast Cells. Frontiers in Immunology. 2021. Dec29:11, 3872. doi:10.3389/fimmu.2020.607048

(members of the GRK are underlined)

18.12.2020

Arnaud Huard and Roland Ebert awarded with a 6-month scholarship

The GRK offers the possibility to apply for a 6-month postdoc scholarship paid by the GRK. To apply for this short-term funding the applicant has to plan a postdoc position out of Germany (letter of intent of the receiving institute) which is funded by a self-raised funding (planned). Both candidates fulfilled these requirements and have now time to finish and submit their applications. Best of luck!

30.11.2020

New Publication Project - Ulrike Weiss

We are happy to announce that our PhD-student Ulrike Weiss published parts of her work of project 8 “The Role of IKKε in the resolution of inflammation in atherosclerosis” (Prof. Ellen Niederberger) in the International Journal of Molecular Sciences with the title “Inhibition of HDAC enzymes contributes to differential expression of pro-inflammatory proteins in the TLR-4 signaling cascade”. Our MD student Sayed Adham Husseini is CoAuthor of this publication. Congratulation!

Reference:

Weiss, U., Möller, M., Husseini, S. A., Manderscheid, C., Häusler, J., Geisslinger, G., Niederberger, E. (2020). Inhibition of HDAC enzymes contributes to differential expression of pro-inflammatory proteins in the TLR-4 signaling cascade. Int J Mol Sci. 2020 Nov 25;21(23):8943. doi: 10.3390/ijms21238943.

(members of the GRK are underlined)

29.10.2020

Warm welcome to our New Project 12 - Dr. Denisa Bojkova

With the new project “SARS-CoV-2 infections in Monocytes/ Macrophages: inflammation patterns and resolution of inflammation” under the supervision of Dr. Denisa Bojkova (Institute of Medical Virology, University Clinic Frankfurt) the GRK was able to recruit a successful young academic working on a contemporary scientific project. The project was evaluated by the DFG and external reviewers and officially affiliated to the GRK as project 12 within the cluster 2.

14.10.2020

New Publication Project 7 - Lisa Kornstädt

In cooperation with her coworker Lisa Hahnefeld our student Lisa Kornstädt (shared first authorship) published parts of her work on “Regulation of resolution of inflammation by mast cells” (project 7/ Prof. Klaus Scholich) in the Journal Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids under the title “Lipidomic analysis of local inflammation models shows a specific systemic acute phase response to lipopolysaccharides”. Congratulation to this success!

Reference:

Hahnefeld, L.*, Kornstädt, L.*, Kratz, D., Ferreirós, N., Geisslinger, G., Pierre, S., & Scholich, K. Lipidomic analysis of local inflammation models shows a specific systemic acute phase response to lipopolysaccharides. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 2021 Sep23; 1866(1), 158822. doi: 10.1016/j.bbalip.2020.158822 * equally contributed.

(members of the GRK are underlined)

01.09.2020

New Publication Project 10 - Giulia Buchmann

We are happy to announce that our PhD-student Giulia Buchmann published parts of her work of project 10 “Role of the NADPH Oxidase NOX4 in the termination of vascular inflammatory reaction after vascular injury” (Prof. Ralf Brandes) in the journal Redox Biology with the title “Deletion of NoxO1 limits atherosclerosis development in female mice. Redox biology”. Congratulation.

Reference:

Buchmann GK, Schürmann C, Warwick T, Schulz MH, Spaeth M, Müller OJ, Schröder K, Jo H, Weissmann N, Brandes RP. (2020) Deletion of NoxO1 limits atherosclerosis development in female mice. Redox biology. 37:101713. doi: 10.1016/j.redox.2020.101713.

(members of the GRK are underlined)

10.08.2020

Recruitment of the new cohort completed

We are happy to announce that we found 10 promising PhD candidates for the second 3-years turnus of our training program. More information will follow soon.

25.06.2020

Prof. Fulda was elected president of the Christian-Albrechts-Universits Kiel

Congratulations to Prof. Fulda (PI project 2) for her election as president of the Christian Albrechts University Kiel. We are sad that she leaves the GRK and project 2 will end with her job change in October, but are certain she will master her new duties very successfully. Congratulation!

01.06.2020

Application window opens today!

Starting October 1st, 2020 we offer 11 PhD student positions within the doctoral program GRK 2336 „Resolution of inflammation – mediators, signaling and intervention“ - go to Application (https://www.grk-ave.de/application/) for more details. Application deadline ends June 30th, 2020.

30.03.2020

New Publication Project 4 - Roland Ebert

Our student Roland Ebert published his work within the GRK project 4 “5-/15-Lipoxigenase interaction as regulatory principle in the lipoxin synthesis during resolution of inflammation” (Prof. Dieter Steinhilber) under the title “Long-term stimulation of toll-like receptor-2 and -4 upregulates 5-LO and 15-LO-2 expression thereby inducing a lipid mediator shift in human monocyte-derived macrophages.” in the journal Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. Congratulation.

Reference:

Ebert R, Cumbana R, Lehmann C, Kutzner L, Toewe A, Ferreirós N, Parnham MJ, Schebb NH, Steinhilber D, Kahnt AS. (2020) Long-term stimulation of toll-like receptor-2 and -4 upregulates 5-LO and 15-LO-2 expression thereby inducing a lipid mediator shift in human monocyte-derived macrophages. Biochim Biophys Acta Mol Cell Biol Lipids. 1865(9):158702. doi: 10.1016/j.bbalip.2020.158702.

(members of the GRK are underlined)

20.03.2019

New Publication Cluster 2 - Associate Tamara Göbel

Our associate member Tamara Göbel (project2, Prof. Dieter Steinhilber) published her work in the journal Frontiers in Pharmacology under the title “Zafirlukast Is a Dual Modulator of Human Soluble Epoxide Hydrolase and Peroxisome Proliferator-Activated Receptor γ.” Congratulation.

Reference:

Göbel T, Diehl O, Heering J, Merk D, Angioni C, Wittmann SK, Buscato E, Kottke R, Weizel L, Schader T, Maier TJ, Geisslinger G, Schubert-Zsilavecz M, Steinhilber D, Proschak E, Kahnt AS. (2019) 1Zafirlukast Is a Dual Modulator of Human Soluble Epoxide Hydrolase and Peroxisome Proliferator-Activated Receptor γ. Front Pharmacol. 0:263. doi: 10.3389/fphar.2019.00263.

(members of the GRK are underlined)